Enzyme Research

Findings from A.J. Davis and co-researchers advance knowledge in enzyme research

Published in AIDS Weekly, March 16th, 2009

According to recent research from Adelaide, Australia, "HIV-1 reverse transcriptase (RT) is a heterodimer composed of p66 and p51 subunits and is responsible for reverse transcription of the viral RNA genome into DNA. RT can be post-translationally modified in vitro which may be an important mechanism for regulating RT activity."

"Here we report detection of different p66 and p51 RT isoforms by 2D gel electrophoresis in virions and infected cells. Major isoforms of the p66 and p51 RT subunits were observed, with pI's of 8.44 and 8.31 respectively (p66(8.44) and p51(8.31)). The same major isoforms were present in virions, virus-infected cell lysates and intracellular...

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Source: AIDS Weekly (2009-03-16)

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