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HIV/AIDS

Scientists at Zhejiang University of Technology describe research in HIV/AIDS

Published in AIDS Weekly, March 16th, 2009

"Two-dimensional (2D) and Three-dimensional (3D) Quantitative Structure-Activity Relationship (QSAR) studies have been carried out on a series of 42 recently synthesized thiourea derivatives to find out the structural requirements of their protection of MT-4 cells against Human Immunodeficiency Virus (HIV)-1 (IIIB). The statistically significant 2D-QSAR model (r(2)=0.897) was developed by Genetic Function Approximation (GFA) when the number of descriptors in equation was set to four, indicating descriptors of S_aaCH, Shadow_XYfrac, Lowest Unoccupied Molecular Orbital (LUMO), and Hydrogen-Bond Acceptors (Hbond Acceptor) mainly control the bioactivity," scientists in Hangzhou, People's...

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