HIV/AIDS

Research in the area of HIV/AIDS reported from University of South Carolina

Published in AIDS Weekly, March 30th, 2009

"In this study we report that primary cultures of rat fetal neurons contain subpopulations of cells that may be sensitive or resistant to HIV-1 Tat neurotoxicity. We demonstrate that rapid binding/uptake of Tat 1-86 for 2 h was sufficient to trigger caspase activation and neurodegeneration in rat fetal midbrain cell cultures," scientists writing in the journal Experimental Neurology report.

"The uptake of Tat was followed by an increase in MCPI (CCL2) immunoreactivity. Approximately 70% of neurons were able to survive transient or Continuous (7 days) Tat exposure. The surviving neurons did not contain bound/internalized Tat, but were able to interact with Tat...

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Source: AIDS Weekly (2009-03-30)

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