HIV/AIDS

New HIV/AIDS research has been reported by scientists at University Hospital

Published in AIDS Weekly, April 6th, 2009

"There is an association between expression of the MHC class I molecule HLA-1327 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single immunodominant viral peptide epitope to CD8(+) T cells," researchers in Freiburg, Germany report.

"If HIV mutates the HLA-B27-binding anchor of this epitope to escape the protective immune response, the result is a less-fit virus that requires additional compensatory clustered mutations. Here, we sought to determine whether the immunodominant HLA-B27-restricted HCV epitope was similarly constrained by analyzing the replication competence and...

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Source: AIDS Weekly (2009-04-06)

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