HIV/AIDS
Study data from M. Alfano and co-authors update knowledge of HIV/AIDS
Published in AIDS Weekly, April 6th, 2009
"Urokinase-type plasminogen activator (uPA) signaling via its receptor uPAR inhibits late events in HIV-1 replication in acutely infected primary monocyte-derived macrophages (MDMs) and promonocytic U937 cells. Here we show that U937-derived, chronically infected U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) express integrins, uPA, and soluble uPAR at levels similar to those of MDMs. uPA inhibited HIV expression in U1 cells incubated with either PMA or tumor necrosis factor-alpha (TNF-alpha), but not with other HIV-inductive cytokines or lipopolysaccharide," scientists in Milan, Italy report.
"Of interest, only PMA and TNF-alpha, but not other...
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Source: AIDS Weekly (2009-04-06)
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