Rockefeller University Press

HIV pays a price for invisibility

Published in AIDS Weekly, April 27th, 2009

Mutations that help HIV hide from the immune system undermine the virus's ability to replicate, show an international team of researchers in the April 13 issue of the Journal of Experimental Medicine. The study was published online on March 23.

When HIV infects a cell, a complex of human immune proteins called HLA (short for human leukocyte antigen) alert killer T cells by displaying bits of the virus on the surface of the cell. The T cells recognize these HIV fragments and mobilize an attack.

Individuals who have certain types of HLA proteins control infection better than others. In people with HLA-B*5703, for example, the virus multiplies less than...

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Source: AIDS Weekly (2009-04-27)

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