HIV/AIDS
Recent studies by C.L. Boutwell and co-authors add new data to HIV/AIDS findings
Published in AIDS Weekly, April 27th, 2009
According to recent research published in the Journal of Virology, "Cytotoxic-T-lymphocyte (CTL) escape mutations in human immunodeficiency viruses encode amino acid substitutions in positions that disrupt CTL targeting, thereby increasing virus survival and conferring a relative fitness benefit. However, it is now clear that CTL escape mutations can also confer a fitness cost, and there is increasing evidence to suggest that in some cases, e. g., escape from HLA-B*57/B*5801-restricted responses, the costs to the escape virus may affect the clinical course of infection."
"To quantify the magnitude of the costs of HLA-B*57/B*5801 escape, a highly sensitive...
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Source: AIDS Weekly (2009-04-27)
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