HIV/AIDS

Research on HIV/AIDS discussed by J.K. Ahluwalia and co-researchers

Published in AIDS Weekly, April 27th, 2009

According to a study from Delhi, India, "Cellular miRNAs play an important role in the regulation of gene expression in eukaryotes. Recently, miRNAs have also been shown to be able to target and inhibit viral gene expression."

"Computational predictions revealed earlier that the HIV-1 genome includes regions that may be potentially targeted by human miRNAs. Here we report the functionality of predicted miR-29a target site in the HIV-1 nef gene. We find that the human miRNAs hsa-miR-29a and 29b are expressed in human peripheral blood mononuclear cells. Expression of a luciferase reporter bearing the nef miR-29a target site was decreased compared to the luciferase...

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Source: AIDS Weekly (2009-04-27)

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