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University Hospital Heidelberg

HIV dearms protective protein in cells

Published in AIDS Weekly, May 11th, 2009

The AIDS-causing HIV specifically counteracts the mechanisms of human cells that protect these against viral infections – a special viral protein marks protective cellular proteins for their rapid destruction and thus diminishes the cell's supply. A team of researchers in Heidelberg under supervision of virologist Dr. Oliver Keppler demonstrated this mechanism for the first time in cell cultures, thus discovering a target for a novel treatment strategy.

Another important discovery of the Heidelberg virologists – this strategy of the human HIV is not effective in a rat model for AIDS. The protective protein in rats is immune to HIV counteraction. Consequently, HIV cannot...

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