HIV/AIDS
New HIV/AIDS study findings have been published by R. Laufer and colleagues
Published in AIDS Weekly, May 18th, 2009
"Human HIV integrase inhibitors are a novel class of antiretroviral drugs that act by blocking incorporation of the proviral DNA into the host cell genome, a crucial step in the life cycle of HIV. In the present work, quantitative methods for prediction of human pharmacokinetics were used to guide the selection of development candidates from a series of dihydroxypyrimidine and N-methylpyrimidinone carboxamide inhibitors of HIV integrase, which are cleared mainly by O-glucuronidation," researchers in Pomezia, Italy report.
"The pharmacokinetics of 10 drugs from this series was determined in several preclinical species, including rats, dogs, rhesus monkeys, and rabbits,...
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Source: AIDS Weekly (2009-05-18)
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