HIV/AIDS

Research from San Francisco General Hospital in HIV/AIDS provides new insights

Published in AIDS Weekly, June 1st, 2009

"Leptin deficiency is associated with dyslipidemia and insulin resistance in animals and humans with lipoatrophy; leptin replacement ameliorates these abnormalities. The objective of the study was to evaluate the effects of leptin therapy in lipoatrophic HIV-infected patients with dyslipidemia and hypoleptinemia," scientists in the United States report.

"This was a 6-month, open-label, proof-of-principle pilot study. Metabolicward studies were performed before and 3 and 6 months after leptin treatment. Participants included eight HIV-infected men with lipoatrophy, fasting triglycerides greater than 300 mg/dl, and serum leptin less than 3 ng/ml. Recombinant human leptin...

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Source: AIDS Weekly (2009-06-01)

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