HIV/AIDS

Study results from West Virginia University in the area of HIV/AIDS published

Published in AIDS Weekly, June 1st, 2009

According to a study from the United States, "Mechanisms responsible for HIV cardiomyopathy are unknown, but may include direct effects of HIV proteins on the heart. Transgenic mice (TG) expressing HIV Tat protein targeted to the myocardium, +/- Tat TG, have revealed anatomical and biochemical defects in the heart."

"The present studies were conducted to clarify the effect of Tat on cardiac function. In vivo hemodynamics was measured in awake mice after inserting a catheter tip in the left ventricle under general anesthesia. Under the age of 3 months, the heart rate (HR) was significantly lower in TG (591 +/- A 47 vs. 716 +/- A 45 bpm, TG versus FVB control (FVB),...

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Source: AIDS Weekly (2009-06-01)

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