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HIV/AIDS
New HIV/AIDS data have been reported by researchers at University of Lausanne
June 15th, 2009
"Besides CYP2B6, other polymorphic enzymes contribute to efavirenz (EFV) interindividual variability. This study was aimed at quantifying the impact of multiple alleles on EFV disposition," researchers in Lausanne, Switzerland report. "Plasma samples from 169 human immunodeficiency virus (HIV) patients characterized for CYP2B6, CYP2A6, and CYP3A4/5 allelic diversity were used to build up a population pharmacokinetic model using NONMEM (non-linear mixed effects modeling), the aim being to seek a general approach combining genetic and demographic covariates. Average clearance (CL) was 11.3l/h with a 65% interindividual variability that was explained largely by CYP2B6...
Source: AIDS Weekly (2009-06-15)
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