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HIV/AIDS

Study findings on HIV/AIDS are outlined in reports from P.C. Matthews and colleagues

Published in AIDS Weekly, June 15th, 2009

"The selection of escape mutations has a major impact on immune control of infections with viruses such as human immunodeficiency virus (HIV). Viral evasion of CD8(+) T-cell responses leaves predictable combinations of escape mutations, termed HLA ''footprints.'' The most clearly defined footprints are those associated with HLA alleles that are linked with successful control of HIV, such as HLA-B*57," scientists in Oxford, the United Kingdom report.

"Here we investigated the extent to which HLA footprint sites in HIV type 1 (HIV-1) are associated with viral evolution among and within clades. First, we examined the extent to which amino acid differences between HIV-1...

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