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HIV/AIDS
Studies from Tulane University further understanding of HIV/AIDS
June 15th, 2009
"The highly active anti-retroviral therapy (HAART) regimen has considerably reduced the mortality rate in HIV-1 positive patients. However, long-term exposure to HAART is associated with a metabolic syndrome manifesting cardiovascular dysfunction, lipodystrophy, and insulin resistance syndrome (IRS)," researchers in the United States report. "The inclusion of HIV-1 protease inhibitors (Pis) in HAART has been linked to the induction of IRS. Although several molecular mechanisms of PI-induced effects on insulin action have been postulated, the deleterious effects of Pis on insulin production by pancreatic beta-cells have not been fully investigated and therapeutic...
Source: AIDS Weekly (2009-06-15)
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