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Anti-Infectives
Research from University of Alabama provides new data on anti-infectives
June 15th, 2009
"The objective of this study was to examine lamivudine (3TC), zidovudine (ZDV), nelfinavir (NFV), and its active nelfinavir metabolite (M8) concentrations in paired maternal plasma and amniotic fluid samples to determine antiretroviral penetration or accumulation in the fetal compartment. Ten paired amniotic fluid and maternal plasma samples were obtained during caesarian section for pharmacokinetic analysis," scientists in the United States report. "Antiretroviral concentrations were measured in both matrices using high-performance liquid chromatography (HPLC) and mass spectrometry (LC/MS) methodologies. Median maternal plasma concentrations for NFV, M8, 3TC, and ZDV...
Source: AIDS Weekly (2009-06-15)
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