HIV/AIDS
Research conducted at National Cancer Institute has updated our knowledge about HIV/AIDS
Published in AIDS Weekly, June 22nd, 2009
According to recent research from the United States, "The maturation inhibitor bevirimat [3-O-(3',3'dimethysuccinyl) betulinic acid; BVM; also known as PA-457 or DSB] potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking protease (PR)-mediated cleavage at the junction between capsid (CA) and spacer peptide 1 (SP1) in Gag. We previously isolated a panel of single-amino-acid substitutions that confer resistance to BVM in vitro (C.S. Adamson, S. D. Ablan, I. Boeras, R. Goila-Gaur, F. Soheilian, K. Nagashima, F. Li, K. Salzwedel, M. Sakalian, C. T. Wild, and E.O. Freed, J. Virol. 80: 10957-10971, 2006)."
"The BVM resistance mutations cluster...
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Source: AIDS Weekly (2009-06-22)
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