HIV/AIDS Co-Infection

Scientists at Case Western Reserve University detail research in HIV/AIDS co-infection

Published in AIDS Weekly, June 29th, 2009

According to recent research from the United States, "Tuberculosis (TB) is a prominent opportunistic infection in HIV-1-infected subjects and enhances HIV-1 replication. TB is associated with excess monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha activity in situ, both of which are implicated in transcriptional activation of HIV-1."

"The role of MCP-1 and TNF-alpha in activation of HIV-1 during TB and by Mycobacterium tuberculosis (MTB) in mononuclear cells from HIV-1/TB subjects with pleural TB was examined here. Extremely high levels of MCP-1 (as compared with TNF-alpha) protein and mRNA were found in pleural fluid and pleural fluid...

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Source: AIDS Weekly (2009-06-29)

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