HIV/AIDS

New HIV/AIDS study findings have been reported from National Institutes of Health

Published in AIDS Weekly, July 6th, 2009

"Using 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one and 4,5-dihydroxy-1H-isoindole-1,3(2H)-dione based HIV-1 integrase inhibitors as display platforms, we undertook a thorough examination of the effects of modifying the halogen substituents on a key benzyl ring that is hypothesized to bind in a hydrophobic pocket of the integrase. DNA complex," scientists in the United States report.

"Data from this study suggest that in general dihalo-substituted analogues have higher potency than monohalo-substituted compounds, but that further addition of halogens is not beneficial," wrote X.Z. Zhao and colleagues, National Institutes of Health.

The researchers...

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Source: AIDS Weekly (2009-07-06)

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