HIV/AIDS

Research conducted at University of Pennsylvania, Medical Department has updated our knowledge about HIV/AIDS

Published in AIDS Weekly, July 6th, 2009

"Lentiviral vector-based gene therapy has been used to target the human immunodeficiency virus (HIV) using an antisense env payload. We have analyzed lentiviral-vector integration sites from three treated individuals," scientists in the United States report.

"We compared integration sites from the ex vivo vector-transduced CD4+ cell products to sites from cells recovered at several times after infusion. Integration sites were analyzed using 454 pyrosequencing, yielding a total of 7,782 unique integration sites from the ex vivo product and 237 unique sites from cells recovered after infusion. Integrated vector copies in both data sets were found to be strongly enriched...

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Source: AIDS Weekly (2009-07-06)

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