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HIV/AIDS
Data on HIV/AIDS described by researchers at Northwestern University
July 6th, 2009
According to recent research from the United States, "HIV-associated lipoatrophy has been associated with mitochondrial dysfunction induced by nucleoside reverse transcriptase inhibitor therapy. We hypothesize that lipid profiles and markers of mitochondrial function will improve in HIV-lipoatrophic patients switched to the nucleotide analogue tenofovir." "Ten patients receiving stavudine, lamivudine and lopinavir/ritonavir (Kaletra (R)) for over 6 years were switched from stavudine to tenofovir for 48 weeks. Subcutaneous fat tissue biopsies, fasting metabolic tests, HIV RNA, CD4 cell count and whole body dual energy X-ray absorptiometry (DEXA) scans were obtained at...
Source: AIDS Weekly (2009-07-06)
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