AIDS Weekly
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HIV/AIDS
Study results from M. Bouillonpichault and colleagues in the area of HIV/AIDS published
July 6th, 2009
According to recent research from Paris, France, "To investigate the possible necessity of an increase in lopinavir dose during pregnancy in order to achieve the concentrations previously defined as predictive of virological efficacy. Lopinavir pharmacokinetics were investigated by a population approach performed on 145 HIV-infected women, including 74 pregnant women." "The final model was used to determine the probability of achievement of the target trough concentrations by Monte Carlo simulations. The typical population estimates (inter-individual variability %) of apparent clearance (CL/F) and volume of distribution were 4.38 L/h (24%) and 58.4 L (59%),...
Source: AIDS Weekly (2009-07-06)
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