Hepatitis C Virus
Researchers at University of Paris target hepatitis C virus
Published in AIDS Weekly, July 27th, 2009
"This report describes the development, optimization and implementation of a persistent cell-based system to test inhibitors of hepatitis C (HCV) translation. The assay is based on a heterologous human immunodeficiency virus-1/simian immunodeficiency virus (HIV-1/SIV) lentiviral vector expressing the bicistronic cassette containing the firefly and renilla luciferase genes, respectively, as reporters, and the HCV internal ribosome entry site (IRES) inserted in between, under the control of the cytomegalovirus (CMV) promoter," scientists in Paris, France report.
"The drug target in this assay is the HCV IRES, the activity of which leads to modulation of the renilla...
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Source: AIDS Weekly (2009-07-27)
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