HIV/AIDS

Data on HIV/AIDS published by researchers at University of Paris

Published in AIDS Weekly, July 27th, 2009

"To assess the relationship between genetic polymorphisms and indinavir pharmacokinetic variability and to study the link between concentrations and short-term response or metabolic safety. Forty protease inhibitor-naive patients initiating highly active antiretroviral therapy (HAART) including indinavir/ritonavir and enrolled in the COPHAR 2-ANRS 111 trial were studied," researchers in Paris, France report.

"At week 2, four blood samples were taken before and up to 6 h following drug intake. A population pharmacokinetic analysis was performed using the stochastic approximation expectation maximization (SAEM) algorithm implemented in MONOLIX software. The area under the...

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Source: AIDS Weekly (2009-07-27)

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