Published in AIDS Weekly, August 17th, 2009
"After experimental CD8(+) cell depletion, elite controlling macaques with set-point viral loads <= 500 viral RNA copies/mL mounted robust Gag- and Nef-specific CD4(+) T cell responses during reestablishment of control with >= 54% of all virus-specific CD4(+) T cells targeting these 2 proteins. Ex vivo, these simian immunodeficiency virus (SIV)-specific CD4(+) T cells neither recognized nor suppressed viral replication in...
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