Pharmacokinetics

Findings in pharmacokinetics reported from G. Krishna and co-researchers

Published in AIDS Weekly, August 31st, 2009

"Patients with HIV/AIDS are at increased risk for opportunistic fungal infections. These patients may require concomitant treatment with antiretrovirals and azole antifungals, and interactions between these classes of drugs should be anticipated," researchers in the United States report.

"A phase 1, open-label, randomized, crossover, drug interaction study was conducted to assess the pharmacokinetic effects of coadministration of posaconazole (400 mg twice daily), with atazanavir (ATV) (300 mg/d alone) and with ritonavir (100 mg/d) or with efavirenz (400 mg/d) in healthy volunteers. Posaconazole increased maximum observed plasma concentration (C-max) and area under the...

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Source: AIDS Weekly (2009-08-31)

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