Published in AIDS Weekly, August 31st, 2009
"Histone deacetylase inhibitors (HDACIs) induce HIV-1 activation from quiescence, yet class/isoform-selective HDACIs are needed to specifically target HIV-1 latency. We tested 32 small molecule HDACIs for their ability to induce HIV-1 activation in the ACH-2 and UI cell line models. In general, potent activators of HIV-1 replication were found among non-class selective and class...
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