HIV/AIDS

Data on HIV/AIDS reported by A. Savarino and co-researchers

Published in AIDS Weekly, August 31st, 2009

"Latently infected, resting memory CD4(+) T cells and macrophages represent a major obstacle to the eradication of HIV-1. For this purpose, ''shock and kill'' strategies have been proposed ( activation of HIV-1 followed by stimuli leading to cell death)," investigators in Rome, Italy report.

"Histone deacetylase inhibitors (HDACIs) induce HIV-1 activation from quiescence, yet class/isoform-selective HDACIs are needed to specifically target HIV-1 latency. We tested 32 small molecule HDACIs for their ability to induce HIV-1 activation in the ACH-2 and UI cell line models. In general, potent activators of HIV-1 replication were found among non-class selective and class...

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Source: AIDS Weekly (2009-08-31)

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