HIV/AIDS
Reports summarize HIV/AIDS research from AIDS Center
Published in AIDS Weekly, August 31st, 2009
According to a study from the United States, "The inhibitory effect of ritonavir on hepatic cytochrome P450 enzymes is a critical factor in achieving optimal levels of co-administered ''boosted'' protease inhibitors (Pis). Even though nonadherence to antiretroviral medications is a common phenomenon, the prevalence of selective ritonavir nonadherence and dose-staggering (i.e., separating ritonavir and boosted PI doses in time) are unknown."
"HIV-1-infected adults receiving a regimen containing ritonavir-boosted atazanavir or fosamprenavir were recruited into a prospective study of adherence and dosage timing of both agents. These parameters were measured over 24 weeks...
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Source: AIDS Weekly (2009-08-31)
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