Life Sciences

Reports outline life sciences study results from M.C. Puertas et al

Published in AIDS Weekly, September 7th, 2009

According to a study from Spain, "A negative association between polymorphism Leu-214 and type-1 thymidine analogue mutations (TAM1) and a positive association with a clinically favorable virological response to thymidine analogue-based combination antiretroviral therapy have been described."

"In this study, the impact of Leu-214 on replication capacity and resistance to zidovudine (ZDV) of viruses containing TAM1 or TAM2 was determined. Leu-214 decreased the growth rate of viruses bearing Tyr-215, as well as their resistance to ZDV," wrote M.C. Puertas and colleagues.

The researchers concluded: "This observation was confirmed by structural and...

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Source: AIDS Weekly (2009-09-07)

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