Published in AIDS Weekly, September 21st, 2009
"Recent data suggest that polyanions have the capacity to enhance HIV type 1 (HIV-1) replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon)," wrote S. Sonza and colleagues.
The researchers concluded: "The enhancement effect is likely to be a function of the assay conditions and is not an...
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