HIV/AIDS

Research results from George Mason University update understanding of HIV/AIDS

Published in AIDS Weekly, October 19th, 2009

According to recent research from the United States, "Preintegration transcription is an early process in human immunodeficiency virus type 1 infection and has been suggested to occur at a low level. The templates have also been suggested to represent a small population of nonintegrated viral DNA, particularly the two-long-terminal-repeat (2-LTR) circles."

"However, these determinations were made by either using PCR amplification of viral transcripts in bulk cell populations or utilizing the LTR-driving reporter cells that measure the synthesis of Tat. The intrinsic leakiness of LTR often makes the measurement of low-level viral transcription inaccurate. Since...

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Source: AIDS Weekly (2009-10-19)

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