Tuberculosis

New findings reported from K. Dheda and co-authors describe advances in tuberculosis

Published in AIDS Weekly, November 9th, 2009

"The diagnosis of smear-negative pulmonary tuberculosis (TB) is problematic. There are limited data on the profile of alveolar TB antigen-specific T cells, and their utility for the rapid immunodiagnosis of pulmonary TB is unclear," investigators in Cape Town, South Africa report.

"Antigen-specific interferon gamma (IFN gamma) responses to the RD-1 antigens ESAT-6 and CFP-10 (T-SPOT. TB and QuantiFERON-TB-Gold-In-Tube), heparin-binding haemagglutinin and purified protein derivative were evaluated, using alveolar lavage cells, in 91 consecutively recruited South African patients suspected of having TB. Of 85 evaluable patients (29% HIV+), 24, 11, 48 and 2 had definite...

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Source: AIDS Weekly (2009-11-09)

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