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Pharmacokinetics

Reports summarize pharmacokinetics research from Chelsea and Westminster Hospital NHS Trust

Published in AIDS Weekly, November 9th, 2009

In this recent report published in the Jaids - Journal of Acquired Immune Deficiency Syndromes, researchers in London, the United Kingdom conducted a study "To. assess the pharmacokinetics of etravirine once and twice daily without and with a preceding efavirenz intake period in healthy volunteers. Volunteers were randomized to receive etravirine 400 mg once daily (arm 1) or 200 mg twice daily (arm 2) for 14 days."

"All subjects underwent a washout period of 14 days and then took efavirenz 600 mg once daily for 14 days. Arm I and 2 restarted etravirine once and twice daily for 14 days. Etravirine pharmacokinetics was assessed for each phase (before and after...

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