HIV/AIDS

Study results from E.N. Kersh and colleagues broaden understanding of HIV/AIDS

Published in AIDS Weekly, November 9th, 2009

According to a study from the United States, "The macaque model of repeated SHIV exposures is increasingly used as a preclinical tool to evaluate biomedical HIV intervention strategies. It is unclear whether multiple virus exposures induce immune responses in macaques, as documented in uninfected individuals repeatedly exposed to HIV."

"We here address whether repeated, rectal SHIVSF162P3 exposures lead to systemic T cell activation in 12 rhesus macaques, and whether this is associated with increased infection resistance. Eight macaques became systemically infected after 2-7 exposures, three macaques were less susceptible (infection after 10-12 exposures), and one...

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Source: AIDS Weekly (2009-11-09)

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