HIV/AIDS

New HIV/AIDS study findings have been reported by researchers at University of Miami, Medical Department

Published in AIDS Weekly, November 23rd, 2009

"The HIV Nef protein mediates endocytosis of surface receptors that correlates with disease progression, but the link between this Nef function and HIV pathogenesis is not clear. Here, we report that Nef-mediated activation of membrane trafficking is bidirectional, connecting endocytosis with exocytosis as occurs in activated T cells," scientists writing in the journal Cell Host & Microbe report.

"Nef expression induced an extensive secretory activity in infected and, surprisingly, also in noninfected T cells, leading to the massive release of microveside clusters, a phenotype observed in vitro and in 36%-87% of primary CD4 T cells from HIV-infected individuals....

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Source: AIDS Weekly (2009-11-23)

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