HIV/AIDS

New HIV/AIDS study findings have been reported by scientists at Heidelberg University

Published in AIDS Weekly, December 14th, 2009

According to recent research published in the journal Retrovirology, "Most retroviruses enter their host cells by fusing the viral envelope with the plasma membrane. Although the protein machinery promoting fusion has been characterized extensively, the dynamics of the process are largely unknown."

"We generated human immunodeficiency virus-1 (HIV-1) particles pseudotyped with the envelope (Env) protein of ecotropic murine leukemia virus eMLV to study retrovirus entry at the plasma membrane using live-cell microscopy. This Env protein mediates highly efficient pH independent fusion at the cell surface and can be functionally tagged with a fluorescent protein. To...

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Source: AIDS Weekly (2009-12-14)

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