Bioengineering
Researchers at Jinan University target bioengineering
Published in AIDS Weekly, December 14th, 2009
"The chemokine receptor, CXCR4, and its specific ligand, CXCL12, have been proven to regulate the directional trafficking and invasion of breast cancer cells to sites of metastases, and similar phenomena have also been identified in many malignant tumors that aberrantly overexpress CXCR4. Therefore, blocking the interaction between CXCR4 and CXCL12 is considered a possible approach to efficiently prevent cancer metastasis," scientists in Guangzhou, People's Republic of China report.
"Employing a cellular phenotypic knockout strategy based on intrakines, we developed a novel recombinant chimeric protein, TAT/54R/KDEL, which contains three distinct functional domains:...
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Source: AIDS Weekly (2009-12-14)
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