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Immunodeficiency

Research on immunodeficiency discussed by S. Fransen and co-researchers

Published in AIDS Weekly, December 14th, 2009

"The human immunodeficiency virus type 1 (HIV-1) integrase mutations N155H and Q148R(H)(K) that reduce susceptibility to the integrase inhibitor raltegravir have been identified in patients failing treatment regimens containing raltegravir. Whether these resistance mutations occur individually or in combination within a single virus genome has not been defined, nor do we fully understand the impact of these primary mutations and other secondary mutations on raltegravir susceptibility and viral replication capacity," scientists writing in the Journal of Virology report.

"To address these important questions, we investigated the raltegravir susceptibility and...

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