Published in AIDS Weekly, January 18th, 2010
"We developed a high-throughput screening assay for Inhibitors of Nef function by coupling it to one of its host cell binding partners; the Src-family kinase Hck. Hck activation is dependent upon Nef in this assay, providing a direct readout of Nef activity in vitro. Using this screen; a unique diphenylfuropyrimidine was identified as a strong inhibitor of Nef-dependent Hck activation. This...
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