HIV/AIDS

Studies from G.F. Salgado et al provide new data on HIV/AIDS

Published in AIDS Weekly, January 18th, 2010

"The molecular mechanism by which HIV-1 Gag proteins are targeted and transported to the plasma membrane after ribosomal synthesis is unknown. In this work, we investigated the potential interaction of p6 and Vpr with model membranes and have determined their binding constants," investigators in Paris, France report.

"Plasmon waveguide resonance (PWR) experiments showed that p6 strongly interacts with membranes (K-d similar to 40 nM), which may help explaining in part why Gag is targeted to and assembles into membranes by coating itself with lipids. Moreover, a substantial increased affinity of Vpr for p6 was observed while in a membrane environment. In order to further...

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Source: AIDS Weekly (2010-01-18)

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