Pneumocystis Carinii Pneumonia

Reports outline pneumocystis carinii pneumonia study findings from Shinshu University, Medical Department

Published in AIDS Weekly, February 1st, 2010

"Pneumocystis pneumonia (PCP) occurs frequently in patients with immunodeficiency syndromes, especially AIDS. In order to investigate the role of IFN-gamma on PCP, nude mice deficient in IFN-gamma (GKO nude) and their wild-type ones (WT nude) were infected with murine Pneumocystis," investigators in Matsumoto, Japan report.

"Nine weeks later they were sacrificed, and cytokines in BALF and lung histopathology were compared between them. Cyst burden was greater in GKO than in WT nude mice. Histopathology in the lung was severer and granulomatous lesions were observed more frequently in GKO nude mice. Levels of IL-17 were higher in BALF of GKO than in that of WT nude mice....

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Source: AIDS Weekly (2010-02-01)

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