HIV/AIDS

New HIV/AIDS study results from Academy of Science described

Published in AIDS Weekly, February 8th, 2010

"HIV integrase (IN) catalyzes the insertion of proviral DNA into the host cell chromosome. While IN has strict sequence requirements for the viral cDNA ends, the integration site preference has been shown to be very diverse," scientists in Prague, Czech Republic report.

"Here, we mapped the HIV IN strand transfer reaction requirements using various short oligonucleotides (ON) that mimic the target DNA. Most double stranded DNA dodecamers served as excellent IN targets with variable integration efficiency depending mostly on the ON sequences. The preferred integration was lost with any changes in the geometry of the DNA double helical structures. Various...

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Source: AIDS Weekly (2010-02-08)

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