Highly Active Antiretroviral Therapy
Researchers from Pondicherry University publish findings in highly active antiretroviral therapy
Published in AIDS Weekly, March 29th, 2010
"HIV infected patients often take at least three anti-HIV drugs together in Highly Active Antiretroviral Therapy (HAART) and/or Ritonavir-Boosted Protease Inhibitor Therapy (PI/r) to suppress the viral replications. The potential drug-drug interactions affect efficacy of anti-HIV treatment and major source of such interaction is competition for the drug metabolizing enzyme, cytorchrome P450 (CYP)," scientists in Pondicherry, India report.
"CYP3A4 isoform is the enzyme responsible for metabolism of currently available HIV-1 protease drugs. Hence administration of these drugs in HARRT or PI/r leads to increased toxicity and reduced efficacy in HIV treatment. We used...
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Source: AIDS Weekly (2010-03-29)
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