HIV/AIDS

Research results from National Institutes of Health update knowledge of HIV/AIDS

Published in AIDS Weekly, March 29th, 2010

Investigators publish new data in the report 'Novel histone deacetylase inhibitors CG05 and CG06 effectively reactivate latently infected HIV-1.' According to recent research from Seoul, Korea, "Histone deacetylase plays an important role in HIV latency. Novel histone deacetylase inhibitors, CG05 and CG06, were evaluated for their roles in HIV latency using ACH2 cells."

"Both inhibitors were highly efficient in reactivation of provirus and exerted lesser toxicity compared with other known histone deacetylase inhibitors. Histone acetylation increased when proviruses were reactivated by the compounds," wrote B.S. Choi and colleagues, National Institutes of Health.

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Source: AIDS Weekly (2010-03-29)

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