HIV/AIDS

Research from E. Fromentin and co-researchers in the area of HIV/AIDS described

Published in AIDS Weekly, March 29th, 2010

According to recent research from the United States, "Nucleoside reverse transcriptase inhibitors (NRTI) require intracellular phosphorylation, which involves multiple enzymatic steps to inhibit the human immunodeficiency virus type I (HIV-1). NRTI-triphosphates (NRTI-TP) compete with endogenous 2'-deoxyribonucleosides-5'-triphosphates (dNTP) for incorporation by the HIV-1 reverse transcriptase (W)."

"Thus, a highly sensitive all lytical methodology capable of quantifying at the low femtomoles/10(6) cells level was necessary to understand the intracellular metabolism and antiviral activity of NRTIs in human peripheral blood mononuclear (PBM) cells and in macrophages. A...

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Source: AIDS Weekly (2010-03-29)

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