HIV/AIDS Genetics

New findings reported from Chiba University describe advances in HIV/AIDS genetics

Published in AIDS Weekly, April 5th, 2010

New research, 'Structural and energetic analysis on the complexes of clinically isolated subtype C HIV-1 proteases and approved inhibitors by molecular dynamics simulation,' is the subject of a report. "HIV-1 has a large genetic diversity. Subtype B HIV-1 is commonly found in patients in developed countries," scientists in Chiba, Japan report.

"In contrast, an increasing number of patients are infected with the non-B subtype viruses, especially with subtype C HIV-1, in developing countries. It remains to be clarified how mutations or polymorphisms in non-B subtype HIV-1 influence the efficacy of the approved inhibitors. In this study, we have performed molecular...

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Source: AIDS Weekly (2010-04-05)

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