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HIV/AIDS Genetics

Study findings from Mount Sinai School of Medicine, Division of Infectious Diseases provide new insights into HIV/AIDS genetics

Published in AIDS Weekly, April 5th, 2010

New investigation results, 'Human peritoneal macrophages from ascitic fluid can be infected by a broad range of HIV-1 isolates,' are detailed in a study published in Journal of Acquired Immune Deficiency Syndromes. "Macrophages are major HIV target cells. They support both productive and latent HIV-1 infection," researchers in the United States report.

"Susceptibility of primary macrophages to HIV depends on the anatomical location and activation state of the cells. We demonstrate that peritoneal macrophages (PMs) are abundant in ascitic fluid of patients with liver cirrhosis and are susceptible to HIV-1 infection. PMs expressed CD68, a differentiation marker,...

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