HIV/AIDS

Investigators at University of Dusseldorf release new data on HIV/AIDS

Published in AIDS Weekly, May 3rd, 2010

"SIVagm does not induce disease in its African green monkey (AGM) host. In comparison, the hybrid simian-human immunodeficiency virus SHIV89.6P that carries the HIV env gene induces disease in rhesus macaques more rapidly than the SIVmac parent virus," researchers in Dusseldorf, Germany report.

"To address the possibility that this enhancement of disease by HIV env would also occur when present in SIVagm, a full-length SIVagm/89.6Penv chimeric lentivirus genome (termed SHIV-MP) was constructed. SHIV-MP replicated similarly to SIVagm in simian peripheral blood mononuclear cells (PBMCs). In inoculated AGMs, rhesus macaques and pig-tailed (FT) macaques the absolute number...

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Source: AIDS Weekly (2010-05-03)

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