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Pediatrics

Data from University of Stellenbosch provide new insights into pediatrics

Published in AIDS Weekly, May 10th, 2010

"Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens," scientists writing in the journal Acta Paediatrica report.

"Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements. Nineteen HIV-infected and 33 HIV-uninfected children received INH...

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