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Essential Amino Acids

Reports from Colorado State University highlight recent research in essential amino acids

Published in AIDS Weekly, May 17th, 2010

Research findings, 'Cysteine 95 and other residues influence the regulatory effects of Histidine 69 mutations on Human Immunodeficiency Virus Type 1 protease autoprocessing,' are discussed in a new report. According to recent research published in the journal Retrovirology, "Regulated autoprocessing of HIV Gag-Pol precursor is required for the production of mature and fully active protease. We previously reported that H69E mutation in a pseudo wild type protease sequence significantly (>20-fold) impedes protease maturation in an in vitro autoprocessing assay and in transfected mammalian cells."

"Interestingly, H69E mutation in the context of a laboratory...

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